Infrared spectroscopic determination of hepatic nuclei oxidation

  1. Get@NRC: Infrared spectroscopic determination of hepatic nuclei oxidation (Opens in a new window)
DOIResolve DOI:<39::AID-BSPY4>3.0.CO;2-N
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Journal titleBiospectroscopy
Pages3945; # of pages: 7
AbstractInfrared spectroscopy was applied to the investigation of normal and oxidatively modified hepatic nuclei. The hepatic nuclei were oxidized by two different free-radical-generating systems. Infrared spectra of oxidized nuclei were remarkably different from those of normal nuclei; the major alteration found in the spectra of oxidized nuclei was the emergence of a new population of nucleic acids with a hydrogen-bonding pattern different from that of the normal phosphodiester groups, and a redistribution of the hydrogen bonding of the protein amide groups of the histones, indicative of protein-structural rearrangements. The spectral changes in the phosphate bands of the nucleic acid resemble those previously observed in different types of malignant tissue, and suggest that there could be a link between nuclei oxidation and carcinogenesis which may involve a free-radical-mediated process.
Publication date
PublisherJohn Wiley & Sons, Inc.
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NRC number408
NPARC number9148533
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Record identifier5dbc6512-0307-40b3-96fc-47c996fc7bc4
Record created2009-06-25
Record modified2016-11-10
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