| Download | - View accepted manuscript: Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells (PDF, 953 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.jneuroim.2009.12.006 |
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| Author | Search for: McCary, Christine; Search for: Tancowny, Brian P; Search for: Catalli, Adriana1; Search for: Grammer, Leslie C.; Search for: Harris, Kathleen E.; Search for: Schleimer, Robert P; Search for: Kulka, Marianna1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Nutrisciences and Health
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| Format | Text, Article |
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| Subject | Stress; Mast cells; IgE, Substance P |
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| Abstract | The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. |
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| Publication date | 2009-12-12 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17326692 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 5d663a36-0248-49b1-b8b5-14f065076ea2 |
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| Record created | 2011-03-18 |
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| Record modified | 2020-04-16 |
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