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Antiproliferative activity of cardenolides isolated from Streptocaulon juventas

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1248/bpb.26.1431
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FormatText, Article
Subjectantiproliferative activity; cardenolides; apoptosis; Streptocaulon juventas; human HT-1080 fibrosarcoma; human lung A549 adenocarcinoma
Abstract
Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine-derived (colon 26-L5 carcinoma, Lewis lung carcinoma, B16-BL6 melanoma) cell lines. The cardenolides selectively and strongly inhibited proliferation of the HT-1080 (IC50 values, 0.054—1.6 μM) and A549 (IC50, 0.016—0.65 μM) cell lines. The characteristic morphological changes and ladder-like DNA fragmentation in those cells treated with the cardenolides indicated the antiproliferative activity was due to the induction of apoptosis.
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  • Biological and Pharmaceutical Bulletin 26, no. 10 (26 October 2003): 1431–1435.
LanguageEnglish
Peer reviewedYes
NRC publication
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NPARC number21274331
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Record identifier46e6c2e2-91d6-4d89-8d4c-f76711fd8103
Record created2015-03-10
Record modified2020-04-02
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