| DOI | Resolve DOI: https://doi.org/10.1088/0957-4484/23/4/045103 |
|---|
| Author | Search for: Hao, Yuzhi1; Search for: Yang, Xiaoyang; Search for: Song, Steven; Search for: Huang, Min; Search for: He, Chuan; Search for: Cui, Mingyang; Search for: Chen, Jie |
|---|
| Affiliation | - National Research Council of Canada. National Institute for Nanotechnology
|
|---|
| Format | Text, Article |
|---|
| Subject | Biodistributions; Biomedical applications; Cell uptake; In-vivo; Nanoparticle sizes; SEM and TEM; Sodium salt; Structural similarity; Biocompatibility; Cell membranes; Thermoplastics; Polyethylene glycols; 1 palmitoyl 2 oleoylglycero 3 phosphoglycerol; 1-palmitoyl-2-oleoylglycero-3-phosphoglycerol; macrogol derivative; metal nanoparticles; phosphatidylglycerol; cell death; drug effect; endocytosis; tumor cell line; ultrastructure; Phosphatidylglycerols; Polyethylene Glycols |
|---|
| Abstract | Recently, there has been a lot of interest in using gold nanoparticles (GNPs) for biomedical applications due to their biocompatibility. To increase GNP cell uptake and circulation half-life, and to improve its bio-distribution invivo, we chose to coat GNPs with 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1- rac-glycerol) (sodium salt) (POPG) and polyethylene glycol (PEG). Two different methods were used to synthesize POPG-GNPs or PEG-GNPs, but the resulting nanoparticle sizes and morphologies were similar. Under the same incubation conditions, POPG-GNPs can be uptaken quicker than PEG-GNPs by cellsspecifically, the maximum uptake was 8h versus 16h after incubation. In addition, the uptake amount of POPG-GNPs was more than that of PEG-GNPs. The uptake processes were confirmed by SEM and TEM images. The main reason for the greater uptake of POPG-GNPs can be attributed to the structural similarities between the POPG coating and the cell membrane as well as GNP aggregation. |
|---|
| Publication date | 2012-01-06 |
|---|
| In | |
|---|
| Language | English |
|---|
| Peer reviewed | Yes |
|---|
| NPARC number | 21270274 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | 338e9260-03b5-4873-8840-694312fb157e |
|---|
| Record created | 2014-01-20 |
|---|
| Record modified | 2020-04-21 |
|---|
