Infection of mice with Francisella as an immunological model

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TypeBook Chapter
Book titleCurrent Protocols in Immunology
Series titleCurrent Protocols in Immunology; Issue Supplement 93
Pages19.; # of pages: 16
Subjectanimal; animal anatomy; article; bacteremia; bacterial skin disease; cytology; disease model; external ear; Francisella tularensis; gastrointestinal tract; immunological procedures; immunology; methodology; microbiological examination; microbiology; mouse; mouse strain; pathogenicity; peritoneal cavity; respiratory tract infection; skeletal muscle; tularemia; Animal Structures; Animals; Bacteremia; Bacteriological Techniques; Disease Models, Animal; Ear Auricle; Francisella tularensis; Gastrointestinal Tract; Immunologic Techniques; Mice; Mice, Inbred Strains; Muscle, Skeletal; Peritoneal Cavity; Respiratory Tract Infections; Skin Diseases, Bacterial; Tularemia
AbstractThis unit describes the utility of various mouse models of infection for studying pathogenesis and adaptive immune responses to the facultative intracellular bacteria pathogen Francisella tularensis. By judicious use of different combinations of mouse and bacterial strains, as well as different routes of infection, murine tularemia models may be used to explore a complete picture of F. tularensis infection and immunity. Moreover, studies using Francisella, particularly the Live Vaccine Strain (LVS), serve as a convenient and tractable model system that appears to be representative of mammalian host responses to intracellular pathogens in general.
Publication date
PublisherJohn Wiley & Sons, Inc
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biological Sciences (IBS-ISB)
Peer reviewedYes
NPARC number21271327
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Record identifier314cde20-499e-4a6e-8995-01bcfcbcc748
Record created2014-03-24
Record modified2016-08-19
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