Alternative title | Probing inhibitory effects of nanocrystalline cellulose using insect cell-based impedance spectroscopy |
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DOI | Resolve DOI: https://doi.org/10.1039/c2nr11886f |
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Author | Search for: Male, Keith B.1; Search for: Leung, C. W.1; Search for: Montes, Johnny1; Search for: Kamen, Amine1; Search for: Luong, John H. T.1 |
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Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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Format | Text, Article |
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Abstract | NCC derived from different biomass sources was probed for its plausible cytotoxicity by electric cell-substrate impedance sensing (ECIS). Two different cell lines, Spodoptera frugiperda Sƒ9 insect cells and Chinese hamster lung fibroblast V79, were exposed to NCC and their spreading and viability were monitored and quantified by ECIS. Based on the 50%-inhibition concentration (ECIS₅₀), none of the NCC produced was judged to have any significant cytotoxicity on these two cell lines. However, NCC derived from flax exhibited the most pronounced inhibition on Sƒ9 compared to hemp and celluslose powder. NCCs from flax and hemp pre-treated with pectate lyase were also less inhibitory than NCCs prepared from untreated flax and hemp. Results also suggested a correlation between the inhibitory effect and the carboxylic acid contents on the NCC. |
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Publication date | 2012-01-04 |
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In | |
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Language | English |
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Peer reviewed | Yes |
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NRC number | NRCC 55427 |
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NPARC number | 21268413 |
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Export citation | Export as RIS |
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Report a correction | Report a correction (opens in a new tab) |
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Record identifier | 2b7c087c-cb59-42f3-98c0-99a169cf5887 |
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Record created | 2013-07-10 |
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Record modified | 2020-04-21 |
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