Advances in metabolite identification

  1. Get@NRC: Advances in metabolite identification (Opens in a new window)
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Journal titleBioanalysis
Pages17691782; # of pages: 14
Subjectchemical analysis; computer program; intermethod comparison; mass spectrometry; metabolism; metabolite; metabolomics; methodology; nuclear magnetic resonance; ultra performance liquid chromatography; Magnetic Resonance Spectroscopy; Mass Spectrometry
AbstractOne of the central challenges to metabolomics is metabolite identification. Regardless of whether one uses so-called 'targeted' or 'untargeted' metabolomics, eventually all paths lead to the requirement of identifying (and quantifying) certain key metabolites. Indeed, without metabolite identification, the results of any metabolomic analysis are biologically and chemically uninterpretable. Given the chemical diversity of most metabolomes and the character of most metabolomic data, metabolite identification is intrinsically difficult. Consequently a great deal of effort in metabolomics over the past decade has been focused on making metabolite identification better, faster and cheaper. This review describes some of the newly emerging techniques or technologies in metabolomics that are making metabolite identification easier and more robust. In particular, it focuses on advances in metabolite identification that have occurred over the past 2 to 3 years concerning the technologies, methodologies and software as applied to NMR, MS and separation science. The strengths and limitations of some of these approaches are discussed along with some of the important trends in metabolite identification. © 2011 Future Science Ltd.
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AffiliationNational Research Council Canada (NRC-CNRC); Security and Disruptive Technologies
Peer reviewedYes
NPARC number21271898
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Record identifier294f2e71-7e7b-4251-9c02-51116d8ac756
Record created2014-05-05
Record modified2016-05-09
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