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DPPH radical scavenging and nitric oxide inhibitory activities of the constituents from the wood of Taxus yunnanensis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1055/s-2003-40641
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Subjectaxus yunnanensis; Taxaceae; DPPH free radical; nitric oxide; lignin; taxane diterpenoids; antiproliferative activity
Abstract
The H2O, H2O/MeOH (1 : 1) and MeOH extracts of the wood of Taxus yunnanensis possessed significant DPPH radical scavenging and nitric oxide (NO) inhibitory activities. Chemical investigation of these extracts led us to isolation of nineteen compounds, i. e., five lignans, two simple phenolics, and twelve taxane-type diterpenes. Isotaxiresinol and seco-isolariciresinol, two major lignans of the wood, possessed potent DPPH radical scavenging activities with IC50 values of 21.7 and 28.9 μM, respectively. Similarly, coniferyl aldehyde, taxusin, 10-deacetyltaxuyunnanine C, hongdoushan A, and 2α,5α,10β-triacetoxy-14β-[(S)-2-methylbutyryloxy]-4(20),11-taxadiene showed potent NO inhibitory activity with IC50 values of 18.0, 22.1, 28.5, 15.0 and 26.4 μM, respectively, which were either equal or lower than the positive control N G-monomethyl-L-arginine (L -NMMA) with an IC50 value of 28.5 μM.
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  • Planta Medica 69, no. 6 (June 2003): 500–505.
LanguageEnglish
Peer reviewedYes
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NPARC number21274346
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Record identifier29240e17-7a23-4dde-99ff-9e0a2a9ee0e7
Record created2015-03-10
Record modified2020-04-02
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