| DOI | Resolve DOI: https://doi.org/10.1016/j.tetlet.2009.08.073 |
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| Author | Search for: Yu, Yi-Ping; Search for: Wu, An-Tai; Search for: Zou, Wei1; Search for: Chen, Chien-Sheng; Search for: Wu, Shih-Hsiung |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | Sialic acid; Wheat germ agglutinin; Surface plasmon resonance; Isothermal titration calorimetry; Molecular modeling |
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| Abstract | Structural divalency between a designed N-acetyl-neuraminic acid (NeuAc)-containing molecule and lectin wheat germ agglutinin (WGA) is investigated. The sialyl molecule was designed based on the NeuAc–WGA complex in the Protein Data Bank and featured polyethylene glycol linkers connecting to an aromatic scaffold. Our results elucidate the divalent recognition association constant between WGA and the multivalent-NeuAc molecules to be 10⁷ by surface plasmon resonance. |
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| Publication date | 2009-11-11 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 15329250 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 1b358419-a306-4fd4-a66b-13ad312daafd |
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| Record created | 2010-05-21 |
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| Record modified | 2020-04-16 |
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