Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.biomaterials.2010.08.094
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Affiliation
  1. National Research Council of Canada
FormatText, Article
Subject3D scaffolds; Cell delivery; Clinical translation; Clinical trial; Engraftment; Ex-vivo; Hemophilia; In-vivo; Mesenchymal stem cell; Nano scale; Osteogenesis; Plasma protein; Porous hydroxyapatite; Practical use; Pre-clinical; Protein delivery; Safety concerns; Self-renewal; Viral vectors; Biomineralization; Cell culture; Flowcharting; Genetic engineering; Hydroxyapatite; Ocean habitats; Proteins; Scaffolds; Stem cells; Gene therapy; biomaterial; blood clotting factor 9; calcium phosphate ceramic; collagen gel; collagen type 1; complementary DNA; green fluorescent protein; hydroxyapatite; plasma protein; polyglactin; retrovirus vector; animal cell; biomineralization; bone development; confocal microscopy; Fourier transformation; gene therapy; hemophilia; hemophilia B; histology; immunohistochemistry; infrared spectroscopy; male; mesenchymal stem cell; mouse; partial thromboplastin time; Western blotting; Calcium Phosphates; Cell Lineage; Cell Proliferation; Ceramics; Factor IX; Gene Therapy; Hemophilia B; Mesenchymal Stem Cells; Mice; Nanoparticles; Particle Size; Porosity; Tissue Scaffolds; Mus
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LanguageEnglish
Peer reviewedYes
NPARC number21271727
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