Vitamin E in young and old human red blood cells

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Journal titleBBA - Biomembranes
Pages8490; # of pages: 7
Subjectalpha tocopherol; arachidonic acid; age; blood and hemopoietic system; cell aging; erythrocyte; human; human cell; Adult; Arachidonic Acid; Arachidonic Acids; Cell Separation; Cholesterol; Erythrocyte Aging; Erythrocytes; Fatty Acids; Human; Middle Age; Support, Non-U.S. Gov't; Vitamin E
AbstractYoung and old human red blood cells contain about the same amount of α-tocopherol, a compound which has previously been shown to be the major lipid-soluble, chain-breaking antioxidant present in such cells. Since red blood cells lose up to ca. 20% of lipid material from their membrane as they age, the α-tocopherol/ membrane-lipid ratio actually rises with age rather than declining as might have been expected on the basis of the free radical theory of aging. The α-tocopherol/arachidonic acid moiety ratios increase in the order: young red blood cells /lt; old red blood cells /lt; plasma, which argues against the suggested membrane 177 stabilizing effect of α-tocopherol/arachidonic acid moiety complexes. © 1986.
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AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276716
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Record identifier1a39cda9-a5bb-49d2-bf94-41468e716c44
Record created2015-10-13
Record modified2016-05-09
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