| DOI | Resolve DOI: https://doi.org/10.1016/j.bmc.2008.09.025 |
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| Author | Search for: Prakesch, Michael1; Search for: Bijian, Krikor; Search for: Campagna-Slater, Valérie; Search for: Quevillon, Sophie1; Search for: Joseph, Reni1; Search for: Wei, Chang-Qing1; Search for: Sesmilo, Esther1; Search for: Reayi, Ayub1; Search for: Poondra, Rajamohan R.1; Search for: Barnes, Michael L.; Search for: Leek, Donald M.; Search for: Xu, Bin; Search for: Lougheed, Caroline; Search for: Schapira, Matthieu; Search for: Alaoui-Jamali, Moulay; Search for: Arya, Prabhat1 |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | natural products; natural product-like compounds; small-molecule chemical probes; diversity-oriented synthesis; focal adhesion kinase; signaling networks; cell migration; anti-cancer agents; docking |
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| Abstract | Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. |
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| Publication date | 2008-11 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 12328434 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 173e4574-524b-44f2-af7c-ab82af098ea8 |
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| Record created | 2009-09-10 |
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| Record modified | 2020-04-15 |
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