Role of PlGF in hypoxia-induced brain

  1. Get@NRC: Role of PlGF in hypoxia-induced brain (Opens in a new window)
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TypeBook Chapter
Book titleJournal of Cerebral Blood Flow and Metabolism
Subjectplacenta-derived growth factor; PlGF; vascular endothelial growth factor; hypoxia-induced brain angiogenesis
AbstractVascular endothelial growth factor (VEGF) mediator family and their receptors are involved in co-ordinated regulation of angiogenesis and neurogenesis after stroke 1. We have recently shown that placenta-derived growth factor (PlGF), a ligand for both VEGFR1 and neuropilin-1 (NP-1), plays a permissive role for VEGF- and astrocyte-induced angiogenic responses of human brain endothelial cells (BEC) 2. The role of PlGF in hypoxia-induced angiogenesis remains unclear.
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AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number21275192
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Record identifier1159e624-0ab0-44c7-875b-22603b059a21
Record created2015-05-22
Record modified2016-05-09
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