| Download | - View accepted manuscript: Characterization of cryoinjury-induced infarction with manganese-and-gadolinium-enhanced MRI and optical spectroscopy in pig hearts (PDF, 847 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.mri.2010.02.001 |
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| Author | Search for: Yang, Yanmin1; Search for: Sun, Jiankang1; Search for: Gervai, Patricia1; Search for: Gruwel, Marco L.1; Search for: Jilkina, Olga1; Search for: Gussakovsky, Eugene1; Search for: Yang, Xi; Search for: Kupriyanov, Valery1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | Acute and chronic cryoinjury; No-reflow embolization; Gd-enhanced MRI; Mn-enhanced MRI; Optical imaging and spectroscopy |
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| Abstract | Purpose: To investigate progression of cryoinjury in pigs using contrast-enhanced magnetic resonance imaging (MRI) as well as optical spectroscopy and imaging. Methods: Cryoinjury was produced in 16 pigs in vivo and investigated using Gd-and Mn-enhanced MRI, optical imaging /spectroscopy and histology in acute and chronic setting up to 4 weeks after the injury. Results: (1) Acute cryoinjury resulted in formation of a lesion with a severely reduced rate of sub-epicardial indocyanine green (intravascular optical flow tracer) passage. In vivo late Gd-enhanced MRI showed a ?10 mm deep hypointense area that was surrounded by a hyperintense rim while ex vivo Mn-enhanced MRI (MEMRI) detected a homogenous hypointense zone. Histological and spectroscopic examination revealed embolic erythrocytes blockages within the cryolesion with a thin necrotic rim neighboring the normal myocardium. (2) Chronic 4-week cryoinjury was characterized by uniform Gd-enhancement, whereas MEMRI revealed reduced Mn2+enhancement. Histological examination showed replacement of the cryoinjured myocardium by scar tissue. Conclusions: Acute cryoinjury resulted in formation of a no-reflow core embolized by erythrocytes and surrounded by a rim of necrotic tissue. Upon injury progression, the no-reflow zone shrunk and was completely replaced with scar tissue by 4 weeks after injury. |
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| Publication date | 2010-04-15 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17653076 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0f9a8683-e9e3-445b-a66d-c6172979949d |
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| Record created | 2011-04-03 |
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| Record modified | 2020-04-17 |
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