Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum

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DOI	Resolve DOI: https://doi.org/10.1021/np0401720
Author	Search for: Linn, Thein Zaw; Search for: Awale, Suresh; Search for: Tezuka, Yasuhiro; Search for: Banskota, Arjun H.; Search for: Kalauni, Surya K.; Search for: Attamimi, Faisal; Search for: Ueda, Jun-ya; Search for: Asih, Puji Budi Setia; Search for: Syafruddin, Din; Search for: Tanaka, Ken; Search for: Kadota, Shigetoshi
Format	Text, Article
Abstract	The CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C−G (1−5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A−C (8−10) and 11 known compounds (norcaesalpinins A−C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 μM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).
Publication date	2005-04-21
In	Journal of Natural Products 68, no. 5 (21 April 2005): 706–710.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274269
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Record identifier	0d116e74-2f3d-46c8-b24e-09eace870463
Record created	2015-03-06
Record modified	2020-04-07

Date modified:: 2024-04-19