Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the Human HT-1080 Fibrosarcoma cell line

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DOI	Resolve DOI: https://doi.org/10.1021/np030177h
Author	Search for: Ueda, Jun-ya; Search for: Tezuka, Yasuhiro; Search for: Banskota, Arjun H.; Search for: Tran, Quan Le; Search for: Tran, Qui Kim; Search for: Saiki, Ikuo; Search for: Kadota, Shigetoshi
Format	Text, Article
Abstract	The methanolic extract of roots of Streptocaulon juventas, having shown strong antiproliferative activity against the highly metastatic human HT-1080 fibrosarcoma cell line, was subjected to activity-guided isolation to yield 16 cardenolides including five new ones, acovenosigenin A 3-O-β-digitoxopyranoside (1), digitoxigenin gentiobioside (2), digitoxigenin 3-O-[O-β-glucopyranosyl-(1→6)-O-β-glucopyranosyl-(1→4)-3-O-acetyl-β-digitoxopyranoside] (3), digitoxigenin 3-O-[O-β-glucopyranosyl-(1→6)-O-β-glucopyranosyl-(1→4)-O-β-digitalopyranosyl-(1→4)-β-cymaropyranoside] (4), and periplogenin 3-O-(4-O-β-glucopyranosyl-β-digitalopyranoside) (5), and two new hemiterpenoids, (4R)-4-hydroxy-3-isopropylpentyl β-rutinoside (6) and (R)-2-ethyl-3-methylbutyl β-rutinoside (7), together with two known phenylpropanoids and a known phenylethanoid. The isolated cardenolides strongly inhibited the proliferation of the HT-1080 cell line (IC50 values, 54−1600 nM).
Publication date	2003-10-23
In	Journal of Natural Products 66, no. 11 (23 October 2003): 1427–1433.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274316
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Record identifier	051be649-9c6b-4874-b960-aa7b3c9d66c5
Record created	2015-03-09
Record modified	2020-04-02

Date modified:: 2024-04-19