| Author | Search for: Schweda, E.; Search for: Richards, J.; Search for: Hood, D.; Search for: Moxon, E. |
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| Format | Text, Article |
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| Subject | bacteria; biosynthesis; chemistry; expression; genetics; gram negative bacteria; Haemophilus; Haemophilus infections; Haemophilus influenzae; heterogeneity; KDO; lipid; lipid A; lipopolysaccharide; LPS; microbiology; molecule; oligosaccharide; pathogenicity; role; structure; substituent; unit; virulence; virulence factors |
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| Abstract | Lipopolysaccharide (LPS) is a major virulence determinant of the human bacterial pathogen Haemophilus influenzae. A characteristic feature of H. influenzae LPS is the extensive intra- and inter-strain heterogeneity of glycoform structure which is key to the role of the molecule in both commensal and disease-causing behaviour of the bacterium. Through the combination of genetics and detailed structural analyses, H. influenzae is an exemplar Gram-negative bacterium for which now the most extensive and detailed LPS structural data and functional correlates are available. LPS from H. influenzae consists of a conserved glucose-substituted triheptosyl inner-core moiety l-alpha-d-Hepp-(1-->2)-[PEtn-->6]-l-alpha-d-Hepp-(1-->3)-[beta-d-Glcp-(1-- >4)]-l-alpha-d-Hepp linked to lipid A via Kdo 4-phosphate. The inner-core unit provides the template for attachment of oligosaccharide- and non-carbohydrate substituents. Here, the structure, genetics and expression of LPS glycoforms in the outer core are reviewed as well as their implication on virulence |
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| Publication date | 2007-09 |
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| In | |
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| Language | English |
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| NRC number | SCHWEDA2007 |
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| NPARC number | 9360549 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0504565e-9201-446e-b392-817f9997da00 |
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| Record created | 2009-07-10 |
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| Record modified | 2020-05-10 |
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